Description

Semaglutide + B6 is a GLP-1 receptor agonist, meaning it mimics a hormone your body naturally produces (glucagon-like peptide-1) that helps regulate appetite, blood sugar, and how full you feel after eating. By extending and amplifying the GLP-1 signal, semaglutide helps slow gastric emptying, reduce appetite, and improve insulin response.

Semaglutide is one of the most widely studied GLP-1 medications and remains a foundational option for medical weight management. Once weekly subcutaneous injection, gradually titrated by your provider.

Benefits patients commonly report

• Reduced appetite and cravings
• Slower digestion that supports prolonged satiety
• Improved blood sugar regulation and metabolic health
• Steady, sustainable progress when paired with lifestyle support
• Lower reactivity to food cues and emotional eating triggers

A note on whole body wellness

As eating patterns become more consistent and hydration habits improve, many patients notice a steadier rhythm to their skin and overall energy.

What to expect

Appetite changes are often felt within the first 1 to 2 weeks. Weight changes typically become visible over 8 to 16 weeks with consistent use and supportive habits. The most commonly reported side effects are gastrointestinal (nausea, constipation, indigestion) and usually subside as your body adjusts.

Who it’s for

Adults pursuing medical weight management whose BMI and medical history meet clinical eligibility criteria. A licensed Fitish provider reviews every intake.

How Fitish RX works

You complete a short online intake about your health and goals. A licensed provider reviews it, and if semaglutide is a fit, writes your prescription. Your medication ships from a licensed compounding pharmacy on a monthly cadence, and your care team stays with you through the patient portal for dose questions and support at no added cost.

Important to know

Compounded semaglutide is prepared by a state licensed sterile compounding pharmacy. Compounded medications are not FDA-approved and do not undergo FDA review for safety, effectiveness, or manufacturing quality. FDA-approved semaglutide products (Ozempic®, Wegovy®, Rybelsus®) are commercially available. Your provider may recommend compounded semaglutide where clinically appropriate based on your evaluation.

Full dose or microdose

Fitish RX offers two distinct GLP-1 lanes so you can match the program to your goal:

• Compounded semaglutide (full dose), $219 / monthly supply. For patients pursuing serious, sustained weight management who meet clinical criteria.
• Microdose semaglutide, $179 / monthly supply. A lower, fixed dose for those who want a gentle, mindful, cosmetic approach rather than full dose weight loss. It does not titrate up.

Both are provider led and ship monthly. If you are not sure which lane fits, complete your intake and your provider will recommend the right one.

These statements have not been evaluated by the Food and Drug Administration. Individual results vary. This product is not intended to diagnose, treat, cure, or prevent any disease.

Not a fit for compounded GLP-1? You may still qualify for our Microdosing program, a lower dose option designed for patients outside the standard BMI range. Eligibility for our compounded GLP-1 program is based on BMI and clinical criteria reviewed by a licensed provider. If your BMI falls below the threshold for compounded GLP-1, you may still be a candidate for our Microdosing program, a lower dose protocol built for patients seeking the metabolic, appetite, and longevity benefits of GLP-1 therapy at a gentler entry point. A provider will review your intake and recommend the program that fits your goals and health profile.

Learn more about Microdosing

Want the gentle lane explained? Read our guide to microdosing semaglutide, or compare starting doses side by side in the GLP-1 microdosing dose chart.

Frequently asked questions

What is compounded semaglutide?

Compounded semaglutide is semaglutide prepared by a state licensed sterile compounding pharmacy and dispensed by prescription. Compounded medications are not FDA-approved. It is used for medically supervised weight management when a licensed provider determines it is appropriate.

How much does compounded semaglutide cost at Fitish?

$219 for a monthly supply, including your provider consult, the medication if approved, and shipping. No separate consult or membership fees.

Do I need insurance?

No. Fitish RX is direct-pay telehealth with transparent, all-in pricing.

Can I pay with my HSA or FSA?

Sometimes. Some plans and cards will go through and others will not, and that part is largely outside our control. Card networks currently treat compounded telehealth prescriptions inconsistently, so an HSA or FSA card can be declined at checkout even when your plan would otherwise allow the expense. Eligibility is determined by your plan and your plan administrator, not by us. If you want to use those funds, the most reliable route is to check with your administrator first, pay with any other card, and submit for reimbursement. Your provider can issue a Letter of Medical Necessity to support that request.

How is it taken?

Semaglutide is a once weekly subcutaneous injection, gradually titrated by your provider and documented in your patient portal.

What are the most common side effects?

Gastrointestinal symptoms such as nausea, constipation, and indigestion are most common and usually subside as your body adjusts. Your provider reviews the full safety profile with you before you begin.

What if I do not qualify for full-dose semaglutide?

You may still be a candidate for the Fitish Microdosing program, a lower dose option for patients who want a gentler, cosmetic approach. Your provider recommends the right program after reviewing your intake.

New to GLP-1? Read our guide to weight loss shots and how they work.

For more detail, see The Clinic FAQ page or our Fitish RX Safety Information. The Black Box warnings, full side effect list, and drug interaction details remain in the Safety Details section below.